A facile and effective procedure for the synthesis of 4-thiazolidinone derivatives using Y(OTf)3 as catalyst |
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| Authors: | Juan Luo Zijun Zhong Hongfu Ji Jiayin Chen Jun Zhao |
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| Affiliation: | Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, School of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, People’s Republic of China |
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| Abstract: | A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5?mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton. |
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| Keywords: | Three-component reaction 4-thiazolidinones thioglycolic acid 1,3-oxathiolan-5-ones yttrium triflate |
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