One-pot synthesis of 1,3-thiazolidin-4-one using ammonium persulfate as catalyst

Ammonium persulfate can be used as a homogeneous catalyst for three-component one-pot synthesis of some 1,3-thiazolidin-4-one derivatives from aldehydes, amines and mercaptoacetic acid under solvent-free conditions with good yields. The characterization of products was generally achieved by IR and NMR techniques. Inexpensive catalyst, high yields, simple product isolation and high atom economy are the noteworthy aspects of the protocols.