Imaging proliferation in vivo with [F-18]FLT and positron emission tomography |
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Authors: | AF Shields JR Grierson BM Dohmen HJ Machulla JC Stayanoff JM Lawhorn-Crews JE Obradovich O Muzik TJ Mangner |
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Affiliation: | Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit Medical Center, MI 48301, USA. shieldsA@karmanos.org |
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Abstract: | Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects. |
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