Extracellular Vesicles as Potential Therapeutics for Inflammatory Diseases |
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| Authors: | Hee Sook Hwang Hyosuk Kim Geonhee Han Jong Won Lee Kwangmeyung Kim Ick Chan Kwon Yoosoo Yang Sun Hwa Kim |
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| Affiliation: | 1.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea; (H.S.H.); (H.K.); (G.H.); (J.W.L.); (K.K.); (I.C.K.);2.Department of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Korea;3.KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Korea;4.Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA |
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| Abstract: | Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques. |
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| Keywords: | extracellular vesicle inflammatory disease EV engineering biomarker |
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