crystSim: A software environment for modelling industrial batch cooling crystallization |
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| Affiliation: | 1. Department of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN 55455, USA;2. Department of Chemical Engineering, The Petroleum Institute, Abu Dhabi, United Arab Emirates;1. Chemical Development Laboratories, CMC Center, Takeda Pharmaceutical Company Limited, 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka, 532-8686, Japan;2. Department of Chemical Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan;1. Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia;2. Sandoz Development Centre Slovenia, Lek d.d., Kolodvorska 27, 1234 Menge?, Slovenia;3. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ve?na pot 113, 1000 Ljubljana, Slovenia;1. Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, United States;2. Alconbury Weston Ltd, Stoke-on-Trent, England, United Kingdom;3. Keit Spectrometers, Harwell Campus, Oxford, England OX11 0QX, United Kingdom;1. School of Chemistry & Chemical Engineering, Southeast University, 211189 Nanjing, China;2. China Academy of Ordnance Science, 100089 Beijing, China;3. Science and Technology on Aerospace Chemical Power Laboratory, 441003 Xiangyang, China |
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| Abstract: | Crystallization modelling is limited by the availability of methods to reliably predict mixing, temperature and concentration distributions, supersaturation, nucleation and growth kinetics for crystallization systems of industrial size. A new software environment for modelling batch cooling crystallization has been developed integrating crystallization and fluid dynamics. The mathematical model can reliably predict mixing in stirred vessels of a given geometry and its effect on the crystallization kinetics and crystal product properties thus reducing the cost and time required for the design and scale-up of industrial crystallizers. The paper describes the development and application of crystSim for modelling industrial crystallization in stirred tanks. The software is developed in Visual C# making full use of Object Oriented Programming (OOP) and multithreading. |
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