Elevated levels of hyaluronic acid in the sera of women with fibromyalgia |
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Authors: | I Yaron D Buskila I Shirazi L Neumann O Elkayam D Paran M Yaron |
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Affiliation: | Department of Rheumatology, Souraski Tel Aviv Medical Center, Tel Aviv University Sackler School of Medicine, Israel. |
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Abstract: | OBJECTIVE: To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). METHODS: HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. RESULTS: HA serum levels (mean microg/l +/- SEM) were 41 +/- 8.7 in healthy controls; 113 +/- 15.9 in RA: and 420 +/- 26 in FM. CONCLUSION: HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis. |
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