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Design of photocontrolled RNA-binding peptidomimetics |
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| Authors: | Mart Robert J Wysoczański Piotr Kneissl Sabine Ricci Antonio Brancale Andrea Allemann Rudolf K |
| Affiliation: | School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK. |
| Abstract: | Positively constrained: the first examples of photocontrolled RNA binding peptides are described. The large number of positively charged sides chains in the Rev response element (RRE) of an HIV type I targeting α-helix imposes constraints on the choice of azobenzene-derived crosslinker. |
| Keywords: | azo compounds peptides photochromism protein modifications RNA recognition |
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