Delivery of drugs and biomolecules using carbon nanotubes |
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| Authors: | Sandeep Kumar Vashist Dan Zheng Giorgia Pastorin Khalid Al-Rubeaan John HT Luong Fwu-Shan Sheu |
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| Affiliation: | aNUSNNI-NanoCore, National University of Singapore, T-Lab Level 11, 5A Engineering Drive 1, Singapore 117580, Singapore;bDepartment of Electrical and Computer Engineering, National University of Singapore, Engineering Drive 1, Singapore 117576, Singapore;cDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore;dDepartment of Pharmacy, National University of Singapore, S4 Science Drive 4, Singapore 117543, Singapore;eUniversity Diabetes Center, King Saud University, P.O. Box 18397, Riyadh 11415, Saudi Arabia;fBiotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada H4P 2R2;gDepartment of Chemistry, University College Cork, Cork, Ireland |
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| Abstract: | Carbon nanotubes (CNTs) have emerged as one of the most advanced nanovectors for the highly efficient delivery of drugs and biomolecules. They offer several appealing features such as large surface areas with well defined physico-chemical properties as well as unique optical and electrical properties. They can be conjugated non-covalently or covalently with drugs, biomolecules and nanoparticles. Albeit some pending concerns about their toxicity in vitro and in vivo, functionalized CNTs appear to exhibit very low toxicity and are not immunogenic. Thus, they could be promising carriers with a great potential for the development of a new-generation delivery system for drugs and biomolecules. There have been significant advances in the field of CNT-based drug delivery, especially in the specific targeting of anticancer and anti-inflammatory drugs for tissues and organs in the body, where their therapeutic effect is highly required. Other promising applications are the delivery of DNA, RNA and proteins. |
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