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Gut Susceptibility to Viral Invasion: Contributing Roles of Diet,Microbiota and Enteric Nervous System to Mucosal Barrier Preservation
Authors:Marcela Julio-Pieper,Alejandra Ló  pez-Aguilera,Johana Eyzaguirre-Velá  squez,Loreto Olavarrí  a-Ramí  rez,Claudia Ibacache-Quiroga,Javier A. Bravo,Gonzalo Cruz
Abstract:The gastrointestinal lumen is a rich source of eukaryotic and prokaryotic viruses which, together with bacteria, fungi and other microorganisms comprise the gut microbiota. Pathogenic viruses inhabiting this niche have the potential to induce local as well as systemic complications; among them, the viral ability to disrupt the mucosal barrier is one mechanism associated with the promotion of diarrhea and tissue invasion. This review gathers recent evidence showing the contributing effects of diet, gut microbiota and the enteric nervous system to either support or impair the mucosal barrier in the context of viral attack.
Keywords:gut   permeability   barrier   epithelium   submucosal neurons   gastrointestinal disorders
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