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Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism |
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| Authors: | Makiko Mochizuki-Kashio Hiroko Shiozaki Toshio Suda Ayako Nakamura-Ishizu |
| Affiliation: | 1.Microanatomy and Developmental Biology, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan;2.Department of Hematology, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan;3.Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, Singapore 117599, Singapore;4.International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan |
| Abstract: | Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis. |
| Keywords: | hematopoietic stem cells ROS mitochondria lysosome autophagy folliculin |