Natural and Designed Toxins for Precise Therapy: Modern Approaches in Experimental Oncology |
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| Authors: | Olga Shilova Elena Shramova Galina Proshkina Sergey Deyev |
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| Affiliation: | 1.Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia; (E.S.); (G.P.);2.Center of Biomedical Engineering, Sechenov University, 119991 Moscow, Russia;3.Research Centrum for Oncotheranostics, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia |
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| Abstract: | Cancer cells frequently overexpress specific surface receptors providing tumor growth and survival which can be used for precise therapy. Targeting cancer cell receptors with protein toxins is an attractive approach widely used in contemporary experimental oncology and preclinical studies. Methods of targeted delivery of toxins to cancer cells, different drug carriers based on nanosized materials (liposomes, nanoparticles, polymers), the most promising designed light-activated toxins, as well as mechanisms of the cytotoxic action of the main natural toxins used in modern experimental oncology, are discussed in this review. The prospects of the combined therapy of tumors based on multimodal nanostructures are also discussed. |
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| Keywords: | targeted toxin pseudomonas exotoxin cancer therapy |
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