Scale-up studies of the supercritical fluid extraction of triterpenic acids from Eucalyptus globulus bark |
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| Affiliation: | 1. CICECO, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal;2. NATEX Prozesstechnologie GesmbH, Werkstrasse 7, 2630 Ternitz, Austria;1. CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro 3810-193, Portugal;2. RAIZ – Forest and Paper Research Institute, Quinta de S. Francisco, Eixo, Aveiro, Portugal;1. Faculty of Food Engineering, Federal University of Pará, Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, Pará, Brazil;2. Faculty of Chemical Engineering, Federal University of Pará, Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, Pará, Brazil;3. Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Biological Sciences, Federal University of Pará, Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, PA, Brazil;4. Faculty of Sciences and Technology, Federal University of Pará, Rua Manoel de Abreu S/N, Multirão, 68440-000 Abaetetuba, Pará, Brazil;1. Institute of Chemical Process Fundamentals, The Czech Academy of Sciences, Rozvojova 135, 165 02 Prague, Czech Republic;2. Crop Research Institute, Drnovska 507/73, 161 06 Prague, Czech Republic |
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| Abstract: | The supercritical fluid extraction (SFE) of Eucalyptus globulus deciduous bark is investigated, under the context of biorefinery, aiming at the definition of a pathway for the production of enriched extracts in triterpenic acids (TTAs). Scale-up studies are performed, well supported by modeling and by experiments carried out at lab, intermediate and pilot scales (0.5, 5.0 and 80.0 L, respectively). By acknowledging the significant role played by cosolvent (ethanol) addition on the concentration of TTAs, extraction curves are measured at 200 bar and 40 °C, using two different ethanol contents, 2.5% and 5.0% (wt). Taking into account the results achieved by four distinct models, the intraparticle diffusion is confirmed as the prevailing mass transfer resistance in both conditions. Accordingly, the ratio between CO2 flow rate and biomass weight is adopted as scale-up criterion. Despite the geometric differences between the three units, the measured extraction yields and TTAs concentration evidence good agreement, which validates the established scale-up rule. In the whole, our results legitimate the technical viability of the SFE of E. globulus deciduous bark for future exploitation at larger scales. |
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| Keywords: | Scale-up Supercritical fluid extraction Modeling |
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