Comparison between effects of standard feed and whole wheat supplemented diet on experimental Eimeria tenella and Eimeria maxima infections in broiler chickens |
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Authors: | L Waldenstedt K Elwinger P Hooshmand-Rad P Thebo A Uggla |
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Affiliation: | Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA. |
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Abstract: | Fas is a surface receptor that can transmit signals for apoptosis. Using retroviral cDNA library-based functional cloning we identified a gene, toso, that blocks Fas-mediated apoptosis. Toso expression was confined to lymphoid cells and was enhanced after cell-specific activation processes in T cells. Toso appeared limited to inhibition of apoptosis mediated by members of the TNF receptor family and was capable of inhibiting T cell self-killing induced by TCR activation processes that up-regulate Fas ligand. We mapped the effect of Toso to inhibition of caspase-8 processing, the most upstream caspase activity in Fas-mediated signaling, potentially through activation of cFLIP. Toso therefore serves as a novel regulator of Fas-mediated apoptosis and may act as a regulator of cell fate in T cells and other hematopoietic lineages. |
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