薯蓣皂苷的抗癌机制研究进展

研究表明薯蓣皂苷具有良好的抗癌活性,可通过参与线粒体途径和死亡受体途径,对活性氧、B淋巴细胞瘤-2基因家族、细胞周期的调控,对信号通路、相关酶类的调节及细胞分化诱导等方面诱导细胞凋亡,从而起到抗癌作用。本文从薯蓣皂苷逆转多药耐药性、抗炎症作用、基质金属蛋白酶的表达、对表皮生长因子的影响及抑制血管生成等方面阐述薯蓣皂苷的抗癌作用机制,最后对其应用发展前景进行展望,以期为薯蓣皂苷作为抗癌药物的开发提供理论依据。

Progress in Research on Anticancer Mechanism of Dioscin

Dioscin has been reported for its good anticancer activity. Dioscin can induce cell apoptosis by regulating reactiveoxygen species, B-cell lymphoma 2 family proteins and cell cycle, modulating signaling pathways and enzymes involved inthem and stimulating cell differentiation through the mitochondrial pathway and the death receptor pathway, and thus exerts ananticancer effect. This paper reviews the anticancer mechanism of dioscin with respect to reversal of multi-drug resistance, antiinflammatoryeffect, expression of matrix metalloproteinases, effect on epidermal growth factor and inhibition of angiogenesis.Finally, prospects for the future development and application of dioscin as an anticancer agent are discussed.