| 壳聚糖/果胶及其衍生物水凝胶的制备与在药物控制释放中的应用 |
| |
| 引用本文： | 郑学芳,杨华,王立升. 壳聚糖/果胶及其衍生物水凝胶的制备与在药物控制释放中的应用[J]. 高分子材料科学与工程, 2009, 25(4) |
| |
| 作者姓名： | 郑学芳 杨华 王立升 |
| |
| 作者单位： | 广西大学化学化工学院,广西,南宁,530004;广西大学化学化工学院,广西,南宁,530004;广西大学化学化工学院,广西,南宁,530004 |
| |
| 摘 要： | 以戊二醛为交联剂制备了壳聚糖/果胶(CS-PT)水凝胶和壳聚糖/辛基果胶水凝胶。研究了制备条件对两种水凝胶溶胀性能的影响。实验表明,交联剂含量、pH、离子强度对CS-PT和壳聚糖/辛基果胶水凝胶溶胀度的影响较大,且在酸性条件下的水凝胶的溶胀度远大于碱性条件下的溶胀度,包埋在水凝胶中的牛血清蛋白在pH=1.0条件下载药的水凝胶释药率大于pH=7.4和pH=9.18条件下的释药率。
|
| 关 键 词： | 壳聚糖/果胶水凝胶 溶胀度 牛血清蛋白 控制释放 |
The Synthesis of Chitosan/Pectin and Derivative Hydrogel and the Application in Drug Controlled Release System |
| |
| ZHENG Xue-fang,YANG Hua,WANG Li-sheng. The Synthesis of Chitosan/Pectin and Derivative Hydrogel and the Application in Drug Controlled Release System[J]. Polymer Materials Science & Engineering, 2009, 25(4) |
| |
| Authors: | ZHENG Xue-fang YANG Hua WANG Li-sheng |
| |
| Affiliation: | College of Chemistry and Chemical Engineering;Guangxi University;Nanning 530004;China |
| |
| Abstract: | pH-sensitive hydrogels based on chitosan-pectin(CS-PT) and chitosan-octyl-pectin were synthesized by using glutaradehyde as cross-link agent.The effects of the degree of the dosage of crosslinking,pH,and ionic strength on the swelling behaviors of two kinds of hydrogels have been studied,and the swelling ratio(SR) of this hydrogel in acide solution is much larger than that in alkaline solution.The release behavior of bovine serum alumin entrapped in the hydrogels was of distinctly difference with the change... |
| |
| Keywords: | chitosan-pectin hydrogel swelling ratio bovine serum alumin controlled release |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
