Beneficial Effects of Supplementation of the Rare Sugar “D‐allulose” Against Hepatic Steatosis and Severe Obesity in Lepob/Lepob Mice |
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Authors: | Kouichi Itoh Shodo Mizuno Sayuri Hama Wataru Oshima Miku Kawamata Akram Hossain Yasuhiro Ishihara Masaaki Tokuda |
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Affiliation: | 1. Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri Univ, Kagawa, Japan;2. Dept. of Pharmacy, Shikoku Medical Center for Children and Adults, Kagawa, Japan;3. Otsuka Pharmaceutical Co, Ltd, Second Tokushima Factory, Bulk Pharmaceutical Chemicals Dept, Second Tokushima Factory, Production Headquarters, Tokushima, Japan;4. Dept. of Cell Physiology, Faculty of Medicine, Kagawa Univ, Kagawa, Japan;5. Research Laboratory, Matsutani Chemical Industry Co. Ltd, Hyogo, Japan;6. Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima Univ, Hiroshima, Japan;7. Rare Sugar Research Center, Kagawa Univ, Kagawa, Japan |
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Abstract: | A rare sugar, D‐allulose (also called D‐psicose), has recently been applied as a food supplement in view of controlling diabetes and obesity in Japan. D‐allulose has been proven to have unique effects against hyperglycemia and hyperlipidemia in a number of studies using several species of rats and mice. However, the antiobesity effects of D‐allulose have not yet been assessed in Lepob/Lepob (ob/ob) mice. Therefore, this study explored the dietary supplemental effects of this sugar in leptin‐deficient ob/ob mice. Consequently, the subchronic ingestion of D‐allulose in ob/ob mice for 15 wk significantly decreased the body and liver weights, and the loss of body weight was involved in the reduction of the total fat mass, including abdominal visceral fat, and not fat‐free body mass, including muscle. Furthermore, D‐allulose improved hepatic steatosis, as evaluated using hepatic histological studies and MRI. In the normal mice, none of these parameters were influenced by the single or long‐term ingestion of D‐allulose. These results indicate that dietary supplementation of D‐allulose especially influences postprandial hyperglycemia and obesity‐related hepatic steatosis, without exercise therapy or dietary restriction. Therefore, D‐allulose may be useful as a supplement for preventing and improving obesity and obesity‐related disorders. |
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Keywords: | D‐allulose dietary supplements hepatic steatosis obesity sugar |
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