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Electrodiffusion Model Simulation of Ionic Channels: 1D Simulations |
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| Authors: | Carl L Gardner Wolfgang Nonner Robert S Eisenberg |
| Affiliation: | 1. Department of Mathematics and Statistics, Arizona State University, Tempe, AZ, 85287, USA 2. Department of Physiology and Biophysics, University of Miami Medical Center, Miami, FL, 33136, USA 3. Department of Molecular Biophysics and Physiology, Rush Medical Center, Chicago, IL, 60612, USA |
| Abstract: | The drift-diffusion (Poisson-Nernst-Planck) model is applied to ionic channels in biological membranes plus surrounding solution baths. Simulations of the K channel in KCl solutions using the TRBDF2 method are presented which show significant boundary layers at the ends of the channel. The computed current-voltage curve for the K channel shows excellent agreement with experimental measurements. |
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