| 2-氰基-4'-甲基联苯的合成研究 |
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| 引用本文： | 刘瑛,马啸华,马淮凌,黄华伟. 2-氰基-4'-甲基联苯的合成研究[J]. 化工时刊, 2006, 20(9): 48-49 |
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| 作者姓名： | 刘瑛 马啸华 马淮凌 黄华伟 |
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| 作者单位： | 河南商丘师范学院化学系,河南,商丘,476000;河南商丘师范学院化学系,河南,商丘,476000;河南商丘师范学院化学系,河南,商丘,476000;河南商丘师范学院化学系,河南,商丘,476000 |
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| 基金项目： | 河南省自然科学基金 , 河南省商丘市科技攻关项目 |
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| 摘 要： | 采用Negishi反应方法,对反应条件进行了优化和改进,以对氯甲苯和邻溴苯基腈为原料,对氯甲苯和镁粉先制成格氏试剂2,然后在溴化亚铜的催化下,通过格氏反应,和邻溴苯基腈进行偶联,以48%的收率制得目标化合物,该方法操作简便,适宜于大规模生产。
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| 关 键 词： | 2-氰基4’-甲基联苯 合成 溴化亚铜 中间体 |
| 收稿时间： | 2006-07-24 |
| 修稿时间： | 2006-07-24 |
Synthesis of 2-Cyano-4'-methylbiphenyl |
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| Liu Ying,Ma Xiaohua,Ma Huailing,Huang Huawei. Synthesis of 2-Cyano-4'-methylbiphenyl[J]. Chemical Industry Times, 2006, 20(9): 48-49 |
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| Authors: | Liu Ying Ma Xiaohua Ma Huailing Huang Huawei |
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| Affiliation: | Department of Chemistry, Shangqiu Normal University Shangqiu 476000 |
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| Abstract: | A practical and convenient synthesis of 2-Cyano-4'-methylbiphenyi was described.The compound 1 was synthesized via Negishi reaction and the method was modified and optimized.In the first 4-chlorotoluene reacted with Mg to generate Grignard reagent 2,then the compound 2 coupled with 2-bromobenzonitrile under the catalyzed of CuBr to produce the target compound in 48% yield. |
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| Keywords: | 2-cyano-4'-methylbiphenyl synthesis CuBr intermediate |
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