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Carbon nanotubes in macrophages: imaging and chemical analysis by X-ray fluorescence microscopy |
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| Authors: | Bussy Cyrill Cambedouzou Julien Lanone Sophie Leccia Emilie Heresanu Vasile Pinault Mathieu Mayne-L'hermite Martine Brun Nathalie Mory Claudie Cotte Marine Doucet Jean Boczkowski Jorge Launois Pascale |
| Affiliation: | Laboratoire de Physique des Solides, UMR 8502 CNRS, Universite Paris Sud, Bat. 510, Orsay F-91405, France. bussy@lps.u-psud.fr |
| Abstract: | X-ray fluorescence microscopy (microXRF) is applied for the first time to study macrophages exposed to unpurified and purified single-walled (SW) and multiwalled (MW) carbon nanotubes (CNT). Investigating chemical elemental distributions allows one to (i) image nanotube localization within a cell and (ii) detect chemical modification of the cell after CNT internalization. An excess of calcium is detected for cells exposed to unpurified SWCNT and MWCNT and related toxicological assays are discussed. |
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