| 壳聚糖/PHB复合缓释微包囊的制备与体外释药评价 |
| |
| 引用本文： | 孟晓荣,黄刚,王琼,杨青翠,张敏. 壳聚糖/PHB复合缓释微包囊的制备与体外释药评价[J]. 材料导报, 2009, 23(12) |
| |
| 作者姓名： | 孟晓荣 黄刚 王琼 杨青翠 张敏 |
| |
| 作者单位： | 1. 西安建筑科技大学理学院,西安,710055
2. 陕西科技大学化工学院,西安,710021 |
| |
| 基金项目： | 国家自然科学基金，陕西省教育厅专项项目，西安建筑科技大学基础研究基金，西安建筑科技大学人才基金 |
| |
| 摘 要： | 用疏水性聚酯PHB外包覆壳聚糖-三聚磷酸钠-阿斯匹林药物缓释体(CPA)制备了壳聚糖/PHB复合缓释微包囊(CPAB),以克服CPA遇酸不稳定的释药特点.用傅立叶红外分光光度计、激光粒度仪、扫描电镜表征了CPAB的组成、粒径及表面形貌.结果显示,CPAB粒径在50～100nm和载药率18.5%时,表面有不均匀的空隙.体外释药评价证实CPAB能有效解决CPA在酸性下的不稳定性,具有长效缓释作用.
|
| 关 键 词： | 壳聚糖 三聚磷酸钠 聚羟基丁酸酯药物缓释 微包囊 |
Preparation and Drug Release Evaluation in vitro of the Compound Chitosan/PHB Microcapsule with Sustained Release of Drug |
| |
| MENG Xiaorong,HUANG Gang,WANG Qiong,YANG Qingcui,ZHANG Min. Preparation and Drug Release Evaluation in vitro of the Compound Chitosan/PHB Microcapsule with Sustained Release of Drug[J]. Materials Review, 2009, 23(12) |
| |
| Authors: | MENG Xiaorong HUANG Gang WANG Qiong YANG Qingcui ZHANG Min |
| |
| Affiliation: | MENG Xiaorong1,HUANG Gang1,WANG Qiong1,YANG Qingcui1,ZHANG Min2(1 School of Science,Xi'an University of Architecture , Technology,Xi'an 710055,2 College of Chemical Engineering,Shaanxi University of Science , Technology,Xi'an 710021) |
| |
| Abstract: | The compound chitosan/PHB microcapsules with sustained release of drug(CPAB)are prepared by chitosan-sodium tripolyphosphate sustained release of Aspirin drug structure(CPA)with coating hydrophobic polyester PHB.CPAB is used to overcome release drug instability of CPA when treated with an acid.The composition,particle size and surface appearance of CPAB are analyzed by FT-IR,SEM and laser granularity apparatus.Results show that the particle size of CPAB ranges from 50nm to 100nm.The drugs loading of CPAB ha... |
| |
| Keywords: | chitosan sodium tripolyphosphate poly-hydroxybutyrate sustained release of drug microcapsule |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
