| 玛咖生物碱通过调节小鼠免疫力抑制结肠癌细胞的成瘤能力 |
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| 引用本文： | 汪颖姣,胡琪,乔旺,黄梦娇,饶勇,刘祖平,刘云,郭庆喜.玛咖生物碱通过调节小鼠免疫力抑制结肠癌细胞的成瘤能力[J].现代食品科技,2019,35(10):38-43. |
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| 作者姓名： | 汪颖姣 胡琪 乔旺 黄梦娇 饶勇 刘祖平 刘云 郭庆喜 |
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| 作者单位： | 西南医科大学临床医学院,四川泸州,646000;西南医科大学药学院,四川泸州,646000;西南医科大学口腔医学院,四川泸州,646000;西南医科大学附属医院,四川泸州,646000 |
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| 基金项目： | 省级大学生创新创业训练计划项目（201710632107） |
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| 摘 要： | 研究观察玛咖生物碱对小鼠结肠癌CT-26细胞成瘤能力的影响并初步探讨其可能机制。构建BALB/c小鼠CT-26细胞移植瘤动物模型，随机分为玛咖生物碱高剂量组、玛咖生物碱低剂量组及生理盐水模型对照组。连续灌胃用药27 d，绘制小鼠体重增长曲线及移植瘤体积增长曲线。第28 d处死小鼠，计算抑瘤率、相对肿瘤增殖率、脾脏指数；ELISA法检测血清IL-2、IFN-γ水平；HE切片观察移植瘤、脾脏、肝脏及肾脏组织学形态变化。结果表明，与对照组比较，实验组移植瘤重量明显降低（p<0.05），抑瘤率分别为43.37%和45.26%，组织学观察实验组移植瘤坏死面积较对照组明显增大。实验组小鼠脾脏指数明显高于对照组（p<0.05），且实验组脾脏白髓增生较显著。同时，血清IL-2及IFN-γ水平均明显高于对照组（p<0.05）。可见，玛咖生物碱可以通过提高小鼠免疫力抑制CT-26细胞的成瘤。
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| 关 键 词： | 玛咖 生物碱 免疫力 结肠癌 成瘤 |
| 收稿时间： | 2019/5/14 0:00:00 |
Study on Ability of Maca Alkaloids to Inhibit Tumor Formation in Colon Cancer by Regulatating Mouse Immunity |
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| WANG Ying-jiao,HU Qi,QIAO Wang,HUANG Meng-jiao,RAO Yong,LIU Zu-ping,LIU Yun and GUO Qing-xi.Study on Ability of Maca Alkaloids to Inhibit Tumor Formation in Colon Cancer by Regulatating Mouse Immunity[J].Modern Food Science & Technology,2019,35(10):38-43. |
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| Authors: | WANG Ying-jiao HU Qi QIAO Wang HUANG Meng-jiao RAO Yong LIU Zu-ping LIU Yun and GUO Qing-xi |
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| Affiliation: | (1.School of Clinical Medicine, Southwest Medical University, Luzhou 646000, China),(2.School of Pharmacy, Southwest Medical University, Luzhou 646000, China),(3.School of Stomatology, Southwest Medical University, Luzhou 646000, China),(3.School of Stomatology, Southwest Medical University, Luzhou 646000, China),(3.School of Stomatology, Southwest Medical University, Luzhou 646000, China),(1.School of Clinical Medicine, Southwest Medical University, Luzhou 646000, China),(1.School of Clinical Medicine, Southwest Medical University, Luzhou 646000, China) and (4.Southwest Medical University Affiliated Hospital, Luzhou 646000, China) |
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| Abstract: | |
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| Keywords: | alkaloid immunity colon cancer tumor formation |
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