梯度多孔载Ag羟基磷灰石陶瓷的制备和性能研究

本文采用添加造孔剂法制备孔隙呈现梯度分布的多孔载Ag羟基磷灰石(Ag-HA)陶瓷。研究了造孔剂分布、烧结温度和载Ag含量对梯度多孔Ag-HA陶瓷孔隙度的影响。分析了烧结产物的物相组成和微观形貌,测量了烧结后梯度多孔Ag-HA陶瓷的压缩性能和抗菌性能。研究结果表明:随着中间层造孔剂含量增加,梯度多孔Ag-HA陶瓷的孔隙度增大,抗压强度减小;随着烧结温度的增大,梯度多孔Ag-HA陶瓷的孔隙度减小,抗压强度增大;当造孔剂分布为20%-10%-20%(质量分数),压制压力为100 MPa,烧结温度为1 150 ℃,Ag含量为2.0%(摩尔分数)时,烧结后梯度多孔2.0Ag-HA陶瓷的孔隙度为24.7%,抗压强度为12.6 MPa。XRD分析表明烧结产物为掺杂Ag离子的HA相。SEM观察表明烧结样品的孔隙呈现梯度分布。梯度多孔Ag-HA陶瓷的抗菌实验表明:随载Ag含量和孔隙度的增大,梯度多孔Ag-HA陶瓷对于大肠杆菌和金黄色葡萄球菌的抑菌圈直径增加,表现出较强的抗菌性能,而纯HA陶瓷未表现出抗菌性能。

Preparation and Properties of Gradient Porous Ag LoadedHydroxyapatite Ceramics

Gradient porous Ag loaded hydroxyapatite (Ag-HA) ceramic was prepared by adding pore-forming agent method.The effects of pore-forming agent distribution,sintering temperature on the porosity were studied.The phase composition and microstructure of the sintered products were analyzed,the compression and antibacterial properties of sintered gradient porous (Ag-HA) ceramics were measured.The experimental results show that the porosity of gradient porous Ag-HA ceramics increases with the increase of the contents of interlayer pore-forming agent,but the compressive strength decreases.With the increase of sintering temperature,the porosity of gradient porous Ag-HA ceramics decreases,but the compressive strength increases.When the distribution of pore-forming agent of is 20%-10%-20% (mass fraction),the pressing pressure is 100 MPa,the sintering temperature is 1 150 ℃ and Ag content is 2% (mole fraction),the porosity and compressive strength of the sintered gradient porous 2.0Ag-HA ceramics are 24.7% and 12.6 MPa,respectively.XRD analysis shows that the sintered products are HA phase doped with Ag ions.SEM observation shows that the pores of sintered samples present gradient distribution.The antibacterial experiments of gradient porous Ag-HA ceramics show that with the increase of Ag loading and porosity,the antibacterial ring diameter of gradient porous Ag-HA ceramics against escherichia coli and staphylococcus aureus increases.The gradient porous Ag-HA has good antibacterial properties,while pure HA ceramic shows no antibacterial properties.