Toxicological evaluation of acetylated faba bean globulin |
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Authors: | Horst Schmandke,Roland Plass,Hans‐Jochen Lewerenz,Dietmar W R Bleyl |
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Abstract: | Acetylated faba bean globulin (acVFG, acetylation degree 97%) was evaluated toxicologically in a subchronic feeding study and a female fertility test. Groups of male and female rats received acVFG in their diet at levels of 20, 40 and 80 g kg−1 for 3 months. Additional groups were fed a commercial diet or given food containing 38 or 75 g kg−1 casein. The subchronic toxicity study revealed growth retardation in both sexes at the 80 g kg−1 acVFG level. The food consumption was reduced in males at 40 and 80 g kg−1 acVFG and in females at 80 g kg−1 acVFG. Histopathological alterations in the ovaries were observed at dietary levels of 40 and 80 g kg−1 acVFG. Histopathological changes and decreases in the absolute and relative weight of the uterus were found in all groups fed acVFG. Therefore a no‐observed‐effect level (NOEL) was not derivable. Feeding females 80 g kg−1 acVFG resulted in diminished pre‐implantation losses but increased post‐implantation losses in the fertility study. © 2000 Society of Chemical Industry |
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Keywords: | acetylated faba bean globulin subchronic oral toxicity study female fertility test rat |
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