| 苯乙酮经Trofimov反应一锅法制备吡咯衍生物的研究 |
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| 引用本文： | 刘焕梅,高雅春,李立军,耿谦,刘文利,孙彩云.苯乙酮经Trofimov反应一锅法制备吡咯衍生物的研究[J].化学世界,2008,49(6):348-350. |
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| 作者姓名： | 刘焕梅 高雅春 李立军 耿谦 刘文利 孙彩云 |
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| 作者单位： | 1. 河北理工大学,轻工学院,河北唐山,063020
2. 河北大学化学与环境科学学院,河北保定,071002 |
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| 基金项目： | 河北省科学技术与发展指导项目 |
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| 摘 要： | 研究了在碳酸氢钠-二甲亚砜催化体系中,酮经Trofimov反应一锅法制备吡咯衍生物。以苯乙酮为原料,生成3-苯基吡咯和1-乙烯基-3-苯基吡咯,反应温度及催化剂的用量对产品收率的影响。其最佳反应条件为:常压,100°C,前者收率为66.2%;后者收率为33.4%。催化剂用量均以NaHCO3/mg:DMSO/mL=420∶10为宜。产物IR及1H NMR均与文献值一致。
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| 关 键 词： | Trofimov反应 苯乙酮 吡咯环化合物 酮肟 |
One-pot Synthesis of Pyrroles from Acetophenone via the Trofimov Reaction |
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| LIU Huan-mai,GAO Ya-chun,LI Li-jun,GENG Qian,LIU Wen-li,SUN Cai-yun.One-pot Synthesis of Pyrroles from Acetophenone via the Trofimov Reaction[J].Chemical World,2008,49(6):348-350. |
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| Authors: | LIU Huan-mai GAO Ya-chun LI Li-jun GENG Qian LIU Wen-li SUN Cai-yun |
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| Abstract: | A one-pot synthesis of pyrroles form ketone via the Trofimov reaction catalyzed by NaHCO_3-DMSO was introduced.Acetophenone was used as starting material to give out 3-phenylpyrrole and 1-vinyl-3-phenylpyrrole.The influence of temperature and catalyst dosage was studied.The optimum reaction conditions were: normal pressure and(100°C).The yield of the former was 66.2%;while the latter was(33.4%).The optimum amount of catalyst for both reactions were the same,i.e.NaHCO_3/mg: DMSO/mL=420∶10.Results of IR and()~1H NMR of the products agreed with those in the literature. |
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| Keywords: | Trofimov reaction: acetophenone: pyrrole compounds ketoxime |
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