| 4-溴-2-丁炔酸甲酯的合成 |
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| 引用本文： | 宋智泉,宋健.4-溴-2-丁炔酸甲酯的合成[J].化学工业与工程,2003(6). |
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| 作者姓名： | 宋智泉 宋健 |
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| 作者单位： | 天津大学药物科学与技术学院，天津大学药物科学与技术学院 天津300072，天津300072 |
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| 摘 要： | 炔丙醇在PPTS催化下由二氢吡喃保护,与溴乙烷格氏试剂反应生成相应的格氏试剂,然后与氯甲酸甲酯反应得到羟基丁炔酸甲酯四氢吡喃醚,在PPTS催化下脱保护后进行甲磺酰化,由溴化钠进行溴取代后合成了4-溴-2-丁炔酸甲酯,总收率达53%。
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| 关 键 词： | 4-溴-2-丁炔酸甲酯 格氏反应 PPTS 炔丙醇 |
Synthesis of Methyl 4-Bromo-2-Butynoate |
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| SONG Zhi-quan,SONG Jian.Synthesis of Methyl 4-Bromo-2-Butynoate[J].Chemical Industry and Engineering,2003(6). |
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| Authors: | SONG Zhi-quan SONG Jian |
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| Abstract: | Propargyl alcohol was protected by dihydrophran with the catalysis of PPTS,and then reacted with Ethyl Mag bromide to prepare its corresponding Grignard reagent.Methyl 4-hydroxy-2-butynoate THP ether was obtained after reacting with methylchloroformate.Deprotection proceeded with the catalysis of PPTS,followed by mesylization and bromide displacement with sodium bromide to give methyl 4-bromo-2-butynoate.The overall yield was 53%. |
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| Keywords: | methyl 4-bromo-2-butynoate Grignard reaction PPTS propargyl alcohol |
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