| 6-甲基-4-对羟苯基-5-乙酰基-3,4-二氢嘧啶-2-酮的合成 |
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| 引用本文： | 裴蕾,宋秋艳,由君,尚岩. 6-甲基-4-对羟苯基-5-乙酰基-3,4-二氢嘧啶-2-酮的合成[J]. 大庆石油学院学报, 2009, 33(3) |
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| 作者姓名： | 裴蕾 宋秋艳 由君 尚岩 |
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| 作者单位： | 哈尔滨理工大学,化学与环境工程学院,黑龙江,哈尔滨,150060;哈尔滨理工大学,化学与环境工程学院,黑龙江,哈尔滨,150060;哈尔滨理工大学,化学与环境工程学院,黑龙江,哈尔滨,150060;哈尔滨理工大学,化学与环境工程学院,黑龙江,哈尔滨,150060 |
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| 摘 要： | 以氨基磺酸为催化剂,对羟基苯甲醛、乙酰丙酮、尿素为原料,在无水乙醇中进行环化缩合反应(Biginelli反应),合成6-甲基-4-对羟苯基-5-乙酰基-3,4-二氢嘧啶-2-酮,并对产品进行表征.结果表明,氨基磺酸具有较好的催化效果,适宜的合成条件为:n(对羟基苯甲醛)∶n(乙酰丙酮)∶n(尿素)=1.0∶2.0∶5.0,氨基磺酸为2.0 g,反应时间为2.0 h,收率可达52.8%.
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| 关 键 词： | 环化缩合反应 3 4-二氢嘧啶-2-酮 氨基磺酸 |
Synthesis of 6-methyl-4-hydroxy benzaldehyde-5-acetyl-3,4-dihydropyrimidin-2-one |
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| PEI Lei,SONG Qiu-yan,YOU Jun,SHANG Yan. Synthesis of 6-methyl-4-hydroxy benzaldehyde-5-acetyl-3,4-dihydropyrimidin-2-one[J]. Journal of Daqing Petroleum Institute, 2009, 33(3) |
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| Authors: | PEI Lei SONG Qiu-yan YOU Jun SHANG Yan |
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| Affiliation: | PEI Lei,SONG Qiu-yan,YOU Jun,SHANG Yan( College of Chemistry and Environment Engineering,Harbin University of Science Technology,Harbin,Heilongjiang 150060,China ) |
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| Abstract: | The syntheses of 6-methyl-4-hydroxy benzaldehyde-5-acetyl-3,4-dihydropyrimidin-2-one by acetylacetone, urea and hydroxyl benzaldehyde using amino sulfonic acid as catalyst and alcohol as solvent are presented . Its structure was confirmed. The results show that amino sulfonic acid has a better catalytic effect. And the optimum reaction conditions are n(aldehyde)∶n(ketone)∶n(urea)=1∶2.0∶5.0, amount of catalyst is 2.0 g aldehyde, reaction time is 2.0 h, the ratio of product up to 54%. |
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| Keywords: | Biginelli reaction 3 4-dihydropyrimidinones aminosulfonic acid |
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