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Structurally Minimized μ‐Conotoxin Analogues as Sodium Channel Blockers: Implications for Designing Conopeptide‐Based Therapeutics |
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| Authors: | Tiffany?S Han Min‐Min Zhang Prof Aleksandra Walewska Pawel Gruszczynski Charles?R Robertson Thomas?E Cheatham III Prof Doju Yoshikami Prof Baldomero?M Olivera Prof Grzegorz Bulaj Prof |
| Affiliation: | 1. Department of Biology, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112 (USA);2. Faculty of Chemistry, University of Gdansk, 80‐952, Gdansk (Poland);3. Intercollegiate Faculty of Biotechnology, University of Gdansk, Medical University of Gdansk, 80‐822, Gdansk (Poland);4. Department of Medicinal Chemistry, University of Utah, 421 Wakara Way, Suite 360, Salt Lake City, UT 84112 (USA), Fax: (+1)?801‐581‐7081 |
| Abstract: | Transforming the neuroactive toxins of cone snails into small‐size compounds poses a challenge due to the presence of multiple disulfide bridges. Herein we describe our successful efforts in minimizing the size of μ‐conotoxin while retaining its biological activity.  |
| Keywords: | backbone spacers conopeptides conotoxins disulfide bridges sodium channels |