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In vitro and in vivo Staining Characteristics of Small,Fluorescent, Aβ42‐Binding D‐Enantiomeric Peptides in Transgenic AD Mouse Models |
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| Authors: | Thomas van?Groen Dr Inga Kadish Dr Katja Wiesehan Dr Susanne?A Funke Dr Dieter Willbold Prof?Dr |
| Affiliation: | 1. Department of Cell Biology, University of Alabama at Birmingham, 1900 University Blvd. THT 912, Birmingham, AL 35294 (USA), Fax: (+1)?205‐934‐7029;2. Forschungszentrum Jülich, INB‐II, Molekulare Biophysik, Wilhelm‐Johnen‐Str., 52428 Jülich (Germany);3. Heinrich Heine Universit?t Düsseldorf, Institut für Physikalische Biologie und BMFZ, Universit?tsstr. 1, 40225 Düsseldorf (Germany) |
| Abstract: | Plaque visualisation : We identified three different D ‐enantiomeric peptides that bind to Alzheimer's amyloid β (Aβ1‐42). As there is currently no definitive pre‐mortem diagnosis for Alzheimer's disease, we investigated the peptides' suitability as molecular probes for in vivo imaging in transgenic mouse models.  |
| Keywords: | aggregation Alzheimer's disease amyloid plaques biotechnology peptides |