1. Department of Chemistry, Syracuse University, Syracuse, NY 13244 (USA), Fax: (+1)?315‐443‐4070;2. N.?C. Brown Center for Ultrastructure Studies, SUNY, College of Environmental Science and Forestry, Syracuse, NY 13210 (USA);3. Department of Exercise Science, Syracuse University, Syracuse, NY 13244 (USA), Fax: (+1)?315‐443‐2258
Abstract:
The cover picture shows three views of a vitamin B12–insulin conjugate bound to transcobalamin II, docked in the insulin receptor (IR). This study reveals how the structure of an orally deliverable insulin changes in solution after vitamin B12 conjugation and its effect on IR binding capacity. The results demonstrate that chemical modification of insulin by linking relatively large pendant groups does not interfere with IR recognition. For more details, see the Full Paper by T. J. Fairchild, R. P. Doyle, et al. on p. 421 ff.
