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Synthesis and Structure–Activity Relationships of 1‐Benzyl‐4,5,6‐trimethoxyindoles as a Novel Class of Potent Antimitotic Agents |
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| Authors: | Mei‐Jung Lai Ching‐Chuan Kuo Dr Teng‐Kuang Yeh Dr Hsing‐Pang Hsieh Dr Li‐Tzong Chen Dr Wen‐Yu Pan Kuang‐Yang Hsu Dr Jang‐Yang Chang Dr Jing‐Ping Liou Dr |
| Affiliation: | 1. College of Pharmacy, Taipei Medical University, 250 Wu‐Xin Street, Taipei 110 (Taiwan, Republic of China), Fax: (+866)?2‐2736‐1661;2. National Institute of Cancer Research, National Health Research Institutes, Tainan 704 (Taiwan, Republic of China), Fax: (+866)?6‐208‐3427;3. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Rd., Zhunan Town, Miaoli County 350 (Taiwan, Republic of China);4. Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 704 (Taiwan, Republic of China) |
| Abstract: | Combretastatin A‐4 derivatives : A series of combretastatin A‐4‐derived 1‐benzyl‐4,5,6‐trimethoxyindoles was designed and prepared as a novel class of potent antimitotic agents acting through the colchicine binding site on the microtubule.  |
| Keywords: | antitumor agents drug design inhibitors structure– activity relationships tubulin polymerization |