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Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing |
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| Authors: | Philippe G Nantermet Dr Hemaka A Rajapakse Dr Mathew G Stanton Dr Shaun R Stauffer Dr James C Barrow Dr Allison R Gregro Keith P Moore Melissa A Steinbeiser John Swestock Harold G Selnick Dr Samuel L Graham Dr Georgia B McGaughey Dr Dennis Colussi Ming‐Tain Lai Dr Sethu Sankaranarayanan Dr Adam J Simon Dr Sanjeev Munshi Dr Jacquelynn J Cook Dr Marie A Holahan Maria S Michener Joseph P Vacca Dr |
| Affiliation: | 1. Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14‐3, West Point, PA 19486 (USA), Fax: (+1)?215‐652‐3971;2. Department of Molecular Systems, Merck Research Laboratories, West Point, PA 19486 (USA);3. Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA 19486 (USA);4. Department of Structural Biology, Merck Research Laboratories, West Point, PA 19486 (USA);5. Department of Imaging, Merck Research Laboratories, West Point, PA 19486 (USA) |
| Abstract: | |
| Keywords: | alzheimer’ s disease aβ reduction inhibitors BACE‐1 β ‐secretase |