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Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli
Authors:Kenji Watanabe Dr  Kinya Hotta Dr  Alex P Praseuth Dr  Mark Searcey Dr  Clay C C Wang Dr  Hiroki Oguri Dr  Hideaki Oikawa Dr
Affiliation:1. Research Core for Interdisciplinary Sciences, Okayama University, Okayama 700‐8530 (Japan), Fax: (+81)?86‐251‐8705;2. Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543 (Singapore);3. Departments of Pharmaceutical Sciences and Chemistry, University of Southern California, Los Angeles, California 90033 (USA);4. Chemical Sciences and Pharmacy, Faculty of Science, University of East Anglia, Norwich NR4 7TJ (UK);5. Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060‐0810 (Japan)
Abstract:
Keywords:antibiotics  biosynthesis  NRPS  protein engineering
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