Synthesis,SAR, and Biological Evaluation of α‐Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis,SAR, and Biological Evaluation of α‐Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors

Authors:	Maria Teresa Rubino Dr. Mariangela Agamennone Dr. Cristina Campestre Dr. Giuseppe Fracchiolla Dr. Antonio Laghezza Dr. Fulvio Loiodice Prof. Elisa Nuti Dr. Armando Rossello Prof. Paolo Tortorella Prof.

Affiliation:	1. Dipartimento Farmaco‐Chimico, Università degli Studi di Bari, Via Orabona 4, 70126 Bari (Italy), Fax: (+39)?080‐5442231;2. Dipartimento di Scienze del Farmaco, Università “G. d'Annunzio”, Via dei Vestini 31, 66013 Chieti (Italy);3. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Pisa, Via Bonanno 6, 56126 Pisa (Italy)

Abstract:	Selective MMP inhibitors : Eleven α‐sulfonylphosphonates were synthesized and tested as MMP inhibitors. The IC₅₀ values for most of them are in the nanomolar range against MMP‐2, ‐8, ‐13, and ‐14, with an interesting selectivity profile versus MMP‐9.

Keywords:	inhibitors matrix metalloproteinases molecular modeling phosphonic acids zinc binding groups