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Development and Characterization of Peptidic Fusion Inhibitors Derived from HIV‐1 gp41 with Partial D‐Amino Acid Substitutions |
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| Authors: | Fabrice Gaston Dr Giovana?C Granados Dr Sergio Madurga Dr Francesc Rabanal Dr Faouzi Lakhdar‐Ghazal Dr Ernest Giralt Prof Elmostafa Bahraoui Prof |
| Affiliation: | 1. Laboratoire d'immuno‐virologie, Université Paul Sabatier, UFR/SVT, 31062 Toulouse (France), Fax: (+33)?561 558 667;2. Institut de Recerca Biomèdica de Barcelona, Parc Cientific de Barcelona, Josep Samitier 1–5 08028 Barcelona (Spain);3. Departament de Química Física de la Universitat de Barcelona‐IQTUB, 08028 Barcelona (Spain) |
| Abstract: | Interactions between C34 and N36 : Synthetic peptides with D ‐amino acid substitutions that mimic the human immunodeficiency virus (HIV) gp41 HR2 region may lead to new peptidic anti‐HIV‐1 drugs that retain potent antiviral activity while being more resistant to proteolytic degradation.  |
| Keywords: | C34 D‐amino acids HIV‐1 inhibitors peptides |