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Nonglycosidic Agonists of Invariant NKT Cells for Use as Vaccine Adjuvants |
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| Authors: | B. Gopal Reddy Dr. Jonathan D. Silk Dr. Mariolina Salio Dr. Rengarajan Balamurugan Dr. Dawn Shepherd Gerd Ritter Dr. Vincenzo Cerundolo Prof. Dr. Richard R. Schmidt Prof. Dr. |
| Affiliation: | 1. Fachbereich Chemie, Universit?t Konstanz, Fach 725, 78457 Konstanz (Germany), Fax: (+49)?7531‐883135;2. Tumour Immunology Group, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Oxford OX3?9DU (UK);3. Ludwig Institute of Cancer Research, Memorial Sloan‐Kettering Cancer Center, 1275 York Avenue, BOX 32, New York, NY 10065 (USA) |
| Abstract: | Based on the crystal structures of human α‐GalCer–CD1d and iNKT–α‐GalCer–CD1d complexes, nonglycosidic analogues of α‐GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen‐specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.  |
| Keywords: | adjuvants ceramide glycolipid analogues synthesis vaccines |