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Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity |
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| Authors: | Xiao‐Qing Feng Yong‐Hong Liang Zhao‐Sen Zeng Fen‐Er Chen Prof?Dr Jan Balzarini Prof?Dr Christophe Pannecouque Prof?Dr Erik De?Clercq Prof?Dr |
| Affiliation: | 1. Department of Chemistry, Fudan University, Shanghai 200433 (P.R. China), Fax: (+86)?21‐6564?3811;2. Institute of Biomedical Science, Fudan University, Shanghai 200433 (P.R. China);3. Rega Institute for Medical Research, Katholieke Universiteit Leuven, 10 Minderbroedersstraat, 3000 Leuven (Belgium) |
| Abstract: | A novel series of diarylpyrimidine analogues (DAPYs) featuring a naphthyl moiety at the C4 position were designed, with all compounds exhibiting strong activity against wild‐type HIV‐1.  |
| Keywords: | antiviral agents DAPYs inhibitors NNRTIs structure– activity relationships |