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Discovery of a New Class of Non‐imidazole Oxazoline‐Based Histamine H3 Receptor (H3R) Inverse Agonists |
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| Authors: | Sylvain Célanire Dr Maikel Wijtmans Dr Bernard Christophe Dr Philippe Collart Iwan de?Esch Dr Donald Dassesse Dr Christel Delaunoy Frédéric Denonne Dr Véronique Durieu Edith Gelens Dr Michel Gillard Dr Bénédicte Lallemand Yves Lamberty Dr Florence Lebon Dr Jean‐Marie Nicolas Dr Luc Quéré Dr Erwin Snip Dr Alain Vanbellinghen Nathalie Van?houtvin Valérie Verbois Henk Timmerman Prof?Dr Patrice Talaga Dr Rob Leurs Prof?Dr Laurent Provins Dr |
| Affiliation: | 1. UCB New Medicines, Chemin du Foriest, 1420 Braine‐L'Alleud (Belgium), Fax: (+32)?2‐3863669;2. Present address: Addex Pharma, Geneva (Switzerland);3. Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Exact Sciences, VU University of Amsterdam, Amsterdam (The Netherlands) |
| Abstract: | H 3 R inverse agonists based on an aminopropoxy‐phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.  |
| Keywords: | cognitive disorders druglike properties histamine H3 receptors structure– activity relationships oxazolines |