Synthesis and Biological Characterization of (3R,4R)‐4‐(2‐(Benzhydryloxy)ethyl)‐1‐((R)‐2‐hydroxy‐2‐phenylethyl)‐piperidin‐3‐ol and Its Stereoisomers for Activity toward Monoamine Transporters
1. Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48202 (USA), Fax: (+1)?313‐577‐2033;2. current address: Piramal Life Sciences, Ltd. Goregaon (East), Mumbai 400?063 (India);3. Virginia Commonwealth University, Richmond, VA 23298 (USA);4. New York University, Department of Psychiatry, New York, NY 10016 (USA)
Abstract:
A novel series of optically active molecules based on a 4‐(2‐(benzhydryloxy)ethyl)‐1‐((R)‐2‐hydroxy‐2‐phenylethyl)‐piperidin‐3‐ol template were developed. Depending on stereochemistry, the compounds exhibit various degrees of affinity for three dopamine, serotonin, and norepinephrine transporters. These molecules have the potential for treating several neurological disorders such as drug abuse, depression, and attention deficit hyperactivity disorder.
