Antitermite Activities of Coumarin Derivatives and Scopoletin from Protium javanicum Burm. f. |
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| Authors: | Morina Adfa Tsuyoshi Yoshimura Kenichi Komura Mamoru Koketsu |
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| Affiliation: | (1) Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan;(2) Research Institute for Sustainable Humanosphere (RISH), Kyoto University, Gokasho, Uji Kyoto, 611–0011, Japan;(3) Department of Chemistry, Bengkulu University, Jl. Raya Kandang Limun, Bengkulu, 38371, Indonesia; |
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| Abstract: | The antitermite (termiticidal and antifeedant) activity of Protium javanicum Burm. f. extract was investigated. The ethyl acetate fraction was active. Scopoletin (1), quercetin, and stigmasterol were isolated by bioassay-guided fractionation. Scopoletin had the highest activity among the three compounds. In order to investigate the structure-activity relationship (SAR) of the methoxy and hydroxy groups at the C-6 and C-7 positions of the coumarin skeleton, we synthesized several coumarin derivatives whose chemical structures are similar to scopoletin. Scopoletin exhibited the strongest termiticidal activity among the 10 compounds tested, followed by 6-methoxycoumarin (3), 6-hydroxycoumarin (7), and umbelliferone (8). All compounds except coumarin (9) showed antifeedant activity. |
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