Preparation of collagen modified photopolymers: a new type of biodegradable gel for cell growth |
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Authors: | Gülay Bayramo?lu Nilhan Kayaman-Apohan Handan Akçakaya Memet Vezir Kahraman Serap Erdem Kuruca Atilla Güngör |
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Affiliation: | (1) Faculty of Engineering, Department of Polymer Engineering, Yalova University, 77100 Yalova, Turkey;(2) Department of Chemistry, Marmara University, 34722 Goztepe-Istanbul, Turkey;(3) Istanbul Faculty of Medicine, Istanbul University, 34390 Capa-Istanbul, Turkey; |
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Abstract: | In this study a new branched methacrylated poly(propylene glycol-co-lactic acid) (PPG–PLA–IEM) and methacrylated cellulose
acetate butyrate resin (CAB–IEM) were synthesized. Hydrogels with various amounts of PPG–PLA–IEM and CAB–IEM (25, 50 and 75 wt%
IEM modified) were prepared by photopolymerization. Collagen tethered PEG–monoacrylate (PEGMA–collagen) was prepared and introduced
as a bioactive moiety to modify the hydrogel in order to enhance cell affinity. In vitro attachment and growth of 3T3 mouse
fibroblasts and human umbilical vein endothelial cells (HUVEC) on the hydrogels with and without collagen were also investigated.
It was observed that, the collagen improves the cell adhesion onto the hydrogel surface. With the increasing amount of collagen,
cell viability increased by 28% for ECV304 (P < 0.05) and 30% for 3T3 (P < 0.05). |
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