Separation of rosmarinic acid by facilitated pertraction |
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| Affiliation: | 1. “Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Dept. of Biomedical Science, M. Kogalniceanu 9-13, 700454 Iasi, Romania;2. “Gheorghe Asachi” Technical University, Faculty of Chemical Engineering and Environmental Protection, Dept. of Biochemical Engineering, D. Mangeron 73, 700050 Iasi, Romania;1. Electrical Engineering, Yale University, New Haven, CT 06511, USA;2. IMEP-LAHC, Grenoble INP Minatec, CS 50257, 38016 Grenoble, France;3. IES, University of Montpellier 2, Montpellier, France;4. Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu 210003, China;5. GLOBALFOUNDRIES, Albany, NY, USA;6. Kyungpook National University, Daegu, Republic of Korea;1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran;2. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz 51664, Iran;3. Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia –Sede Bogotá, Cra. 30 No. 45-03, Bogotá D.C., Colombia;4. Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA;1. Department of Physical Chemistry and Department “Science and Technology of Life, Light and Matter”, University of Rostock, Dr-Lorenz-Weg 1, D-18059 Rostock, Germany;2. Department of Physical Chemistry, Kazan Federal University, Kremlevskaya str. 18, 420008 Kazan, Russia |
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| Abstract: | Rosmarinic acid has been separated by facilitated pertraction with D2EHPA dissolved in dichloromethane. The pertraction has been carried out in presence of 1-octanol, added into the liquid membrane. The addition of the alcohol led to the increase for more than twice the rosmarinic acid initial and final mass flows, this effect being directly related to the process variables (pH-gradient between the aqueous phases, carrier and alcohol concentrations inside the membrane phase, mixing intensity). But, the influence of 1-octanol on the transport capacity of the pertraction system was negative, its addition inducing the accumulation of rosmarinic into the liquid membrane. Due to this effect, the reevaluation and optimization of the reextraction process from the membrane phase to the stripping are required. |
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| Keywords: | Rosmarinic acid Liquid membrane Facilitated pertraction D2EHPA Mass flow Permeability factor |
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