| β-胡萝卜素的合成工艺改进 |
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| 引用本文： | 皮士卿,沈润溥,赵国庆,潘亚金,陈新志.β-胡萝卜素的合成工艺改进[J].精细化工,2004,21(8):605-607. |
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| 作者姓名： | 皮士卿 沈润溥 赵国庆 潘亚金 陈新志 |
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| 作者单位： | 1. 浙江大学,材料与化工学院,浙江,杭州,310027
2. 浙江医药股份有限公司,新昌制药厂,浙江,绍兴,312500 |
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| 摘 要： | 采用Wittig Horner法合成β 胡萝卜素,以3 甲基 5 (2,6,6 三甲基 1 环己烯 1 基) 1,3(或1,4) 戊二烯膦酸二烷基酯直接与2,7 二甲基 2,4,6 庚三烯 1,8 二醛反应合成目标产物,收率60%,与JamesH.Bable所申请的专利(US:4916250,1990)的方法相比不但省掉了一步碱催化的双键重排反应,而且收率提高10%。1HNMR,IR,MS显示与对照品一致。
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| 关 键 词： | WittigHorner反应 碱催化双键重排 β-胡萝卜素 多双键烷基膦酸酯 |
| 文章编号： | 1003-5214(2004)08-0605-03 |
Improved Method of Wittig-Horner Reaction for the Synthesis of β-Carotene |
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| PI Shi-qing,SHEN Run-pu,ZHAO Guo-qing,PAN Ya-jin,CHEN Xin-zhi.Improved Method of Wittig-Horner Reaction for the Synthesis of β-Carotene[J].Fine Chemicals,2004,21(8):605-607. |
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| Authors: | PI Shi-qing SHEN Run-pu ZHAO Guo-qing PAN Ya-jin CHEN Xin-zhi |
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| Affiliation: | PI Shi-qing~1,SHEN Run-pu~1,ZHAO Guo-qing~2,PAN Ya-jin~2,CHEN Xin-zhi~ |
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| Abstract: | β -Carotene was synthesized by Wittig-Horner reaction.3-Methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3(or 1,4)-pentadienylphosphonate reacted directly with 2,7-dimethyl-2,4,6-octatriene-1,8-dial to give the desired product in 60% yield.Compared with the literatures,not only the step of base-catalyzed double bond migration was curtailed but also the yield was improved by 10%.~1HNMR,IR and MS showed that the desired product was identical with criterion. |
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| Keywords: | Wittig-Horner reaction base-catalyzed double bond migration β -carotene multi double bond alkylphosphonate ester |
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