| 中间体5-氨基-2-氯-4-氟苯硫基乙酸甲酯的制备 |
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| 引用本文： | 杜晓华,顾建波,徐振元. 中间体5-氨基-2-氯-4-氟苯硫基乙酸甲酯的制备[J]. 农药, 2003, 42(1): 14-15 |
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| 作者姓名： | 杜晓华 顾建波 徐振元 |
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| 作者单位： | 1. 浙江工业大学催化加氢研究中心,杭州,310014
2. 浙江威尔达化工有限公司,杭州,310018 |
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| 摘 要： | 由4－氯－2－氟乙酰苯胺经氯磺化、还原、水解制得5－氨基－2－氯－4－氟苯硫酚，然后与氯乙酸甲酯反应制备了中间体5－氨基－2－氯－4－氟苯硫基乙酸甲酯，该路线原料易得，操作方便，是一条可行的工艺路线。
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| 关 键 词： | 中间体5－氨基－2－氯－40氟苯硫基乙酸甲酯 制备 2－氟－4－氯乙酰苯胺 中间体 |
| 修稿时间： | 2002-08-20 |
The Preparation of Methyl 5-Amino-2-Chloro-4-Fluorophenylthioacetate |
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| Du Xiaohua et al.. The Preparation of Methyl 5-Amino-2-Chloro-4-Fluorophenylthioacetate[J]. Pesticides, 2003, 42(1): 14-15 |
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| Authors: | Du Xiaohua et al. |
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| Abstract: | The intermediate methyl 5-amino-2-chloro-4-fluorophenylthioacetate was prepared using 4-chloro-2-fluoroacetanilide as a starting material 4-Chloro-2-fluoroacetanilide was converted into 5-amino-2-chloro-4-fluorothiophenol by three reaction steps including chlorosulfonation,reduction and hydrolysis,followed by reacting with methyl chloroacetate to give the titled compound The synthesis route is practicable for the advantages such as readily available materials and reagents and moderate and operationally simple conditions |
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| Keywords: | methyl 5-amino-2-chloro-4-fluorophenylthioacetate 4-chloro-2-fluoroacetanilide preparation intermediate |
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