| 2-乙基-6-甲基-3-羟基吡啶的合成优化 |
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| 引用本文： | 周泽建,王京刚,刘世普,姚兴圣. 2-乙基-6-甲基-3-羟基吡啶的合成优化[J]. 河北化工, 2007, 30(11): 8-8,19 |
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| 作者姓名： | 周泽建 王京刚 刘世普 姚兴圣 |
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| 作者单位： | 1. 北京化工大学化学工程学院,北京,100029
2. 山东潍坊祥维斯化学品研发中心,山东,潍坊,261041 |
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| 摘 要： | 2-乙基-6-甲基-3-羟基吡啶盐酸盐是一种新型的抗氧化药物.对其游离碱即标题产物合成工艺进行改进:以2%三氟化硼的乙醚稀溶液为催化剂合成2-丙酰基-5-甲基呋喃,产率为71%;再在150℃下25%氨水中加入一定量的铵盐,高压下合成2-乙基-6-甲基-3-羟基吡啶,有效地减少了焦油的生成,同时避免了大量铵盐结块对高压釜的损害,标题化合物的产率达50.3%,并通过1HNMR对产物进行了表征.
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| 关 键 词： | 2-乙基-6-甲基-3-羟基吡啶 三氟化硼 氯化铵 |
| 文章编号： | 1003-5095（2007）11-0008-02 |
| 修稿时间： | 2007-08-27 |
Synthesis of 2-ethyl-6-methyl-3-hydroxypyridine with An Improved Process |
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| ZHOU Ze-jian,WANG Jing-gang,LIU Shi-pu,YAO Xing-sheng. Synthesis of 2-ethyl-6-methyl-3-hydroxypyridine with An Improved Process[J]. Hebei Chemical Engineering and Industry, 2007, 30(11): 8-8,19 |
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| Authors: | ZHOU Ze-jian WANG Jing-gang LIU Shi-pu YAO Xing-sheng |
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| Abstract: | 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride is a new synthetic antioxidant. Improvement for the preparation of its base:the acylation of 2-methylfuran with propionic anhydride has resulted in a 71% yield of 2-propionyl-5-methylfuran in the presence of 2% boron trifluoride-etherate;conditions to obtain the product in good yield have been established. |
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| Keywords: | 2-ethyl-6-methyl-3-hydroxypyridine boron fluoride ammonium chloride |
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