| 虫草头孢菌粉抗心律失常活性成分的分离纯化及结构鉴定 |
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| 引用本文： | 邹峥嵘,陈贝贝,王如伟,姚新生.虫草头孢菌粉抗心律失常活性成分的分离纯化及结构鉴定[J].食品科学,2012,33(21):149-152. |
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| 作者姓名： | 邹峥嵘 陈贝贝 王如伟 姚新生 |
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| 作者单位： | 1.江西师范大学生命科学学院
2.浙江中药与天然药物研究院
3.深圳中药及天然药物研究中心 |
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| 摘 要： | 目的：研究虫草头孢(Cephalosporium sinensis)菌粉的抗心律失常活性成分。方法：在活性检测结果的指导下，采用硅胶柱色谱法、ODS RP C18高效液相色谱法分离纯化虫草头孢菌粉中的抗心律失常活性化学成分，根据化合物的理化性质和波谱数据鉴定其化学结构。结果：从虫草头孢菌粉乙醇提取物的水饱和正丁醇萃取部位中分离得到5个化合物，分别是尿苷(化合物1)、胸苷(化合物2)、腺苷(化合物3)、2’-脱氧尿苷(化合物4)、尿嘧啶(化合物5)。结论：核苷类化合物为虫草头孢菌粉中的主要的抗心律失常成分。
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| 关 键 词： | 虫草头孢菌粉 抗心律失常 活性成分 |
| 收稿时间： | 2011-09-06 |
Separation,Purification and Structural Identification of Antiarrhythmic Constituents in Cephalosporium sinensis Mycelia |
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| ZOU Zheng-rong,CHEN Bei-bei,WANG Ru-wei,YAO Xin-sheng.Separation,Purification and Structural Identification of Antiarrhythmic Constituents in Cephalosporium sinensis Mycelia[J].Food Science,2012,33(21):149-152. |
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| Authors: | ZOU Zheng-rong CHEN Bei-bei WANG Ru-wei YAO Xin-sheng |
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| Affiliation: | 1.College of Life Science,Jiangxi Normal University,Nanchang 330022,China; 2.Zhejiang Institute of Traditional Chinese Medicine and Natural Medicine,Hangzhou 310052,China; 3.Shenzhen Research Center of Traditional Chinese Medicine and Natural Products,Shenzhen 518057,China) |
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| Abstract: | Objective: To study antiarrhythmic constituents in Cephalosporium sinensis mycelia. Methods: Antiarrhythmic constituents in Cephalosporium sinensis mycelia were separated and purified by silical gel column chromatography and ODS RP C18 HPLC and structurally identified according to physio-chemical properties and spectral data. Results: Five active compounds were separated from the water saturated butanol-soluble fraction of ethanolic extract from Cephalosporium sinensis mycelia, including uridine, thymidine, 2’-deoxyuridine and uracil. Conclusion: The main antiarrhythmic constituents in Cephalosporium sinensis mycelia are nucleosides. |
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| Keywords: | Cephalosporium sinensis antiarrhythmic active constituents |
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