金钗石斛多糖对小鼠抗疲劳能力的作用

目的：研究金钗石斛水溶性、碱溶性和酸溶性多糖对小鼠抗疲劳能力的影响。方法：对照组每天以蒸馏水灌胃，实验组以500mg/(kg·d)金钗石斛多糖灌胃，连续4周后进行强迫性游泳实验，测定小鼠游泳时间和游泳后甘油三酯、血糖、血乳酸、血氨和糖原等生化指标变化。结果：与蒸馏水相比，金钗石斛多糖，特别是碱溶性多糖可显著廷长游泳时间，提高血糖和甘油三酯含量并降低血乳酸和血氨含量，降低游泳后肝糖原及肌糖原的消耗。结论：金钗石斛多糖通过增加脂肪利用以及延缓乳酸和氨的积累达到抗疲劳作用。

Anti-fatigue Effects of Polysaccharides Derived from Dendrobium nobile Lindl. in Mice

Purpose: To investigate the anti-fatigue effects of polysaccharides derived from Dendrobium nobile Lindl (DNP) in mice. Methods: The anti-fatigue effect of polysaccharides was evaluated based on the forced swimming performance and the changes of biochemical parameters in ICR mice. Mice were orally administrated with DNP at a dose of 500 mg/(kg·d) day for 4 successive weeks to create a treatment group and those given distilled water every day were assigned to a control group. After the end of the 4-week administration period, all mice were subjected to weight-loaded forced swim test and then measured for swimming time and biochemical indicators such as blood triglyceride, blood sugar, blood ammonia and glycogen. Results: Compared with distilled water, DNP especially alkaline-soluble DNP could significantly lengthen the swimming time of mice, increase blood triglyceride and glucose levels, and reduce blood lactic acid and ammonia levels, and post-swimming hepatic and muscle glycogen consumption in mice. Conclusion: DNP can exert anti-fatigue effects in mice by increasing fat utilization and delaying the accumulation of plasma lactic acid and ammonia.