Homogeneous chitosan/carbonate apatite/citric acid nanocomposites prepared through a novel in situ precipitation method |
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| Affiliation: | 1. Institute of Analytical and Biomedical Science, College of Chemistry and Molecular Sciences, Wuhan 430072, PR China;2. Center of Nano-Sciences and Nano-Technology Research, Wuhan University, Wuhan 430072, PR China;3. School & Hospital of Stomatology, Wuhan University, Wuhan 430072, PR China;1. Institute of Multipurpose Utilization of Mineral Resources, CAGS, Chengdu 610041, China;2. School of Resource and Civil Engineering, Wuhan Institute of Technology, Wuhan 430073, China;1. Department of Pharmaceutics, YSPM’S Yashoda Technical Campus, Faculty of Pharmacy, Wadhephata, Satara 415011, Maharashtra, India;2. Department of Pharmacology, School of Pharmacy, SRTM University, Nanded, 431 606, Maharashtra, India;1. Department of Food Science and Engineering, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran;2. Center of Excellence for Application of Modern Technologies for Producing Functional Foods and Drinks (FFDCE), University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran;3. Interdisciplinary Research Department of Agricultural and Natural Resources Nanotechnology (IRDANN), University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran;1. Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona, 08028, Spain;2. Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Spain;3. School of Engineering & Materials Science, Queen Mary, University of London, London, E1 4NS, UK;4. G.I.R. Bioforge, University of Valladolid, Valladolid, 47001, Spain;5. Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia (UPC), Barcelona, 08028, Spain |
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| Abstract: | Homogeneous nanocomposites composed of carbonate apatite and chitosan in the presence of citric acid were synthesized by a novel in situ precipitation method. The morphological and componential properties of composites were investigated. The carbonate apatite particulates, in sizes of about 50–100 nm, were distributed within the network chitosan hydrogel homogeneously, moreover, inorganic particles could be controlled by the size of networks of organic matrix which was mediated with crosslink degree of chitosan. Through highly magnified TEM observation, it can be shown that inorganic particles were composed of more fine sub-particles whose diameters were between 2 and 5 nm in size without regular crystallographic orientation. The concept of multiple-order template mediation was brought forward for the first time. A novel hierarchical porous nanocomposite scaffold was also prepared by multilevel freeze-drying technique and its mechanical performance had obvious increase compared with neat chitosan. These results provided an efficient approach toward new biomimetic tissue scaffold for the biomedical applications with enhanced intensity/bioactivity and controlled resorption rates. |
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