Nanogel-modified polycaprolactone microfibres with controlled water uptake and degradability |
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Authors: | Dominic Kehren Astrid Catalina Molano LopezAndrij Pich |
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Affiliation: | Functional and Interactive Polymers, DWI RWTH Aachen University, Forckenbeckstr. 50, D-52056 Aachen, Germany |
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Abstract: | In this work we prepared composite poly(caprolactone) (PCL) microfibres decorated with temperature-sensitive poly(N-vinylcaprolactam) nanogels by an one-step electropsinning process. Microfibres with variable internal structure were prepared by using two different solvent systems: methanol/toluene (Me/Tol) and chloroform/dimethylformamide (Ch/DMF). Our experimental data shows that the nature of the solvent mixtures allows obtaining microfibres with different morphologies: Microfibres with nanogels on the fibre surface (Me/Tol) and microfibres with nanogels in the fibre interior (Ch/DMF). The morphology of composite fibres was visualized by scanning electron microscopy (SEM) and their properties investigated by differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA) and contact angle measurements. The results show that combining hydrophobic poly(caprolactone) with hydrophilic nanogels leads to microfibres exhibiting controlled swelling in water. Additionally, the thermo-sensitive properties of the nanogels are maintained whether they are on the surface or inside of the fibres. The presence of nanogels in the fibre structure also allows regulating their degradability. |
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Keywords: | Nanogels Electrospinning Composite material |
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