Full surface embedding of gold clusters on silicon nanowires for efficient capture and photothermal therapy of circulating tumor cells |
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Authors: | Park Gyeong-Su Kwon Hyuksang Kwak Dong Wook Park Seong Yong Kim Minseok Lee Jun-Ho Han Hyouksoo Heo Sung Li Xiang Shu Lee Jae Hak Kim Young Hwan Lee Jeong-Gun Yang Woochul Cho Hoon Young Kim Seong Keun Kim Kinam |
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Affiliation: | Samsung Advanced Institute of Technology, San 14-1, Nong-Seo Ri, Ki-Hung Eub, Yong-In Gun, Kyung-Ki Do 449-900, South Korea. gs8144.park@samsung.com |
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Abstract: | We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (~88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells. |
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