Controlled prospective study of postpartum mood disorders: Psychological, environmental, and hormonal variables.

Demographic, psychiatric, social, cognitive, and life stress variables were used to determine the etiology of depression in childbearing (CB; n?=?182) and nonchildbearing (NCB; n?=?179) women. Hormonal variables in postpartum depression were also evaluated. In the CB group predictors of depression diagnosis were previous depression, depression during pregnancy, and a Vulnerability (V)?×?Life Stress (LS) interaction; predictors of depressive symptomatology were previous depression, depressive symptoms during pregnancy, life events, and V?×?LS. Only estradiol was associated with postpartum depression diagnosis. In the NCB group V?×?LS was the only predictor of depression diagnosis; depressive symptoms during pregnancy and life events were predictors of depressive symptomatology. Previous findings about depression vulnerability were replicated. The significant V?×?LS interactions support the vulnerability-stress model of postpartum depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)